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#P13
POSTER SESSION I:
MULTIMODAL RECEPTION;
CHEMOSENSATION & DISEASE;
TASTE PERIPHERY; OLFACTION PERIPHERY
OERP differences as a function of age, the Apolipoprotein E
(ApoE) ε4 allele, electrode site, and response type during
retrieval using odor labels in an odor-recognition memory task
Lisa V. Graves
1
, Melissa R. Cervantez
1
, Amanda J. Green
2
,
Charlie D. Morgan
1
, Claire Murphy
1,2
1
San Diego State University San Diego, CA, USA,
2
University of California, San Diego La Jolla, CA, USA
Alzheimer’s disease affects 5.4 million Americans. Evidence
suggests that individuals who are ApoE ε4+ are at higher risk for
developing the disease. Studies have also shown that ApoE ε4 is
linked to olfactory decline. Olfactory functioning may be
investigated using olfactory event-related potentials (OERP).
The high temporal resolution of OERP enables an understanding of
the neural correlates of olfactory processing and functioning. This
study investigated the effects of age, ApoE ε4 status, electrode site,
and response type on OERP latency and amplitude during retrieval
in an odor-recognition memory task. Participants were divided into
3 equal age groups: younger, middle, and older. Each subgroup had
an equal number of ApoE ε4+ and ε4- individuals. The study
design was composed of separate visual and olfactory components.
The odors were presented with a computer-controlled olfactometer.
Both visual and olfactory retrieval sessions were conducted.
Participants were notified during encoding that this was a task of
odor memory. Results indicated differences in OERP activity
between individuals who are ApoE ε4+ versus ApoE ε4- during
retrieval using odor labels. These findings highlight the potential
for OERP to differentiate between ApoE ε4+ and ApoE ε4-
individuals. Acknowledgements: Supported by NIH grant #
DC00264-14 from the National Institute on Deafness and Other
Communication Disorders. We thank Paul Gilbert for his
statistical expertise, and Jessica Bartholow, Roberto Zamora,
Ariana Stickel, Derek Snyder, Kyle Sigel, Jean-Loup Bitterlin,
Kristina Constant, and Sanae Okuzawa for their assistance with
data collection and entry.
#P14
POSTER SESSION I:
MULTIMODAL RECEPTION;
CHEMOSENSATION & DISEASE;
TASTE PERIPHERY; OLFACTION PERIPHERY
Chemical intolerance in patients with rhinologic diseases
Woo Yong Bae, Tae Kyung Koh
Dept. of Otorhinolaryngology, Dong-A University Busan, Korea
Various environmental agents adversely affect the quality of life in
the general population and many diseases may be associated with
the chemical intolerance, but the exact mechanisms are lacking. In
some of the ENT diseases, environmental agents can induce or
aggravate the symptoms of each disease. In allergic rhinitis (AR),
allergic symptoms can be manifested by the nonspecific odorants,
which are not associated with airborne antigen(s). We investigated
the prevalence of the chemical intolerance of rhinologic diseases
using QEESI and compared the prevalence rate. Next, we
compared the chief complaint and ARIA classification of AR with
the degree of suggested chemical intolerance. Compared to the
control group, the prevalence rate of very suggestive cases was
higher in rhinologic diseases, especially AR, chronic rhinosinusitis
(CRS), and non-allergic rhinitis (NAR). In AR, the rate of very
suggestive scores was about 15%. When we compared the chief
complaint according to the degree, in the cases of very suggestive
scores, rhinorrhea occurred more than nasal obstructions. In the
very suggestive cases, all have the persistent/ moderate-severe
classification. In the CRS cases, we divided them into 3 groups -
CRS without nasal polyp (NP), with NP and with AR. The groups
with AR or NP had more very suggestive scores than the group
without AR or NP. In the NAR group, the finding was very similar
to the AR group. The prevalence rate of chemical intolerance is
higher in rhinologic diseases, especially AR, CRS and NAR. Many
rhinologic diseases, including AR can be aggravated and caused by
environmental factors. More advanced control of those diseases can
be accomplished with more study on chemical sensitivity.
#P15
POSTER SESSION I:
MULTIMODAL RECEPTION;
CHEMOSENSATION & DISEASE;
TASTE PERIPHERY; OLFACTION PERIPHERY
Pain-relieving effect of olfactory exposure in patients with
chronic back pain?
Daniel Baum, Thomas Hummel, Antje Haehner
Smell & Taste Clinic, Department of Othorhinolaryngology,
University of Dresden Medical School Dresden, Germany
Aim:
The aim of this investigation was to find out whether patients
suffering from chronic back pain would benefit from short-term
exposure to odors in terms of an increase in pain thresholds to
electrical stimulation of the fore-arm.
Methods:
A group of patients
with chronic back pain was analyzed in reference to olfactory
function, pain threshold, and mental health state. Short-term odor
exposure was performed over a period of four weeks. Patients were
exposed to four odors (rose, vanilla, chocolate, peach) every two
hours during daytime. The patients’ pain threshold was obtained
before and after the training using electrical stimulation. Olfactory
testing was performed before and after training using the Sniffin
Sticks.
Results:
Compared to baseline measurements electrical
pain thresholds in patients tended to be higher (P=0.09) after the
training period. A significant increase of olfactory function
however, was not found.
Conclusions:
The present results indicate
that olfactory training may increase pain threshold in patients with
chronic back pain.
#P16
POSTER SESSION I:
MULTIMODAL RECEPTION;
CHEMOSENSATION & DISEASE;
TASTE PERIPHERY; OLFACTION PERIPHERY
Olfactory Dysfunction is Associated with Reduced
Sexual Appetite
Volker Gudziol
1
, Silvia Wolff- Stefan
2
, Katja Aschenbrenner
2,3
,
Peter Joraschky
2
, Thomas Hummel
1
1
Smell and Taste Clinic, University of Dresden Medical School
Dresden, Germany,
2
Department of Psychotherapy and
Psychosomatic, University of Dresden Medical School Dresden,
Germany,
3
The John B. Pierce Laboratory and Department of
Psychiatry, Yale University New Haven, CT, USA
Introduction: Individual reports from patients about sexual
dysfunction since the onset of smell loss was the motivation for the
present study. The study aimed to investigate sexual appetite and
depression in relation to olfactory function in patients with self
reported smell loss. Methods: One-hundred-twenty-five patients
who complained about reduced sense of smell were enrolled in the
study. The sense of smell was evaluated by tests for odor threshold
Abstracts | 33
Abstracts are printed as submitted by the author(s)
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