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34
in WR-AN. BCAA administration effectively reduced the
TRP/ΣLNAA ratio, providing a new approach for assessing
serotonin-related symptoms in WR-AN. Supported by R21
MH071689 and the Bernice S. Weisman Fund.
T33
MITOCHONDRIAL DYSFUNCTION IN BULIMIA NERVO-
SA (BN) : A PILOT STUDY
Allan S Kaplan
1,2,3
, Vanessa Gonçalves
1
, Zeynep Yilmaz
1,2
,
Robert Levitan
1,2,3
, James Kennedy
1,2,3
1
Center for Addiction and Mental Health, Toronto, ON,
Canada,
2
Institute of Medical Science, Toronto, ON, Canada,
3
Faculty of Medicine, Toronto, ON, Canada
Purpose:
Recent studies suggest that mitochondria play a
role in psychiatric disorders through their control of brain en-
ergy homeostasis and metabolism. The aims of this study are
1) to examine mitochondrial DNA (mtDNA) in BN as the fluc-
tuations in metabolic rate and energy intake in BN may be in-
fluenced by or affect mitochondrial functioning. 2) to examine
if mutations on mtDNA are associated with subphenotypes
of BN, i.e, lifetime weight fluctuation and a history of AN.
Methods:
We will sequence the whole mitochondrial genome
for 240 BN subjects and 165 healthy controls using 5500
SOLiD next generation sequencing. This case-control study
will allow us to investigate the presence of specific mutations
in the mitochondrial genome that could lead to impairment in
mitochondrial metabolic pathways in BN probands.
Results:
The mean age of the BN sample was 25 years, the mean BMI
was 22.4. Prevalence of lifetime comorbidities was: mood
disorder 76%, anxiety disorder 59%, and anorexia nervosa
33%. Data from the mitochondrial DNA analysis, which is un-
derway, will be presented, including the presence of specific
mutations in the mitochondrial genome.
Conclusions:
This
study of mitochondrial dysfunction in BN, the first of its kind
that we are aware, may shed light on cellular and molecular
mechanisms involved in BN and assist with the identification
of new candidate genes to examine, and, eventually, contrib-
ute to the development of novel pharmacological approaches
T34
THE RELATIONSHIP BETWEEN EATING DISORDER EX-
AMINATION QUESTIONNAIRE SUBSCALE SCORES AND
SUBSTANCE USE SEVERITY IN WOMEN WITH COMOR-
BID PTSD AND SUBSTANCE USE DISORDERS
Therese K Killeen
1
, Timothy D Brewerton
1
, Aimee N Camp-
bell
2
, Lisa Cohen
2
, Denise A Hien
3
1
Department of Psychiatry & Behavioral Sciences, Charles-
ton, SC, USA,
2
Columbia University, New York, NY, USA,
3
City University of New York, New York, NY, USA
Introduction:
Eating disorders (EDs) and substance use
disorders (SUDs) commonly co-occur, especially in con-
junction with PTSD, yet little is known about ED symptoms
in women presenting to addiction treatment programs. We
hypothesized an association between severity of ED & SUD
symptoms in a sample of treatment seeking women with
comorbid SUD & PTSD.
Method:
Participants were 122
women from 4 treatment sites who participated in a multi-site
clinical trial through NIDA’s clinical trial network (CTN). The
Eating Disorder Examination-Questionnaire (EDE-Q) and the
Addiction Severity Index (ASI) were administered at base-
line. Nonparametric correlation coefficients (Spearman rho)
between EDE-Q subscale scores and selected ASI variables
were calculated using SPSS.
Results:
Scores on the Eating,
Weight and Shape Concern subscales of the EDE-Q were
significantly correlated with past 30 day cocaine, methadone,
other opiate & polysubstance abuse. All 4 EDE-Q subscale
scores were significantly correlated with the number of days
experiencing drug problems in the past 30 days. There were
also significant correlations with number of yrs of use of
opiates, hallucinogens & sedative/hypnotics.
Conclusion:
These findings suggest a positive relationship between addic-
tion severity and ED symptoms, particularly those involving
weight and shape concerns. Assessing and addressing ED
symptoms in addiction treatment programs may improve the
treatment needs of this patient subgroup.
T35
CONDUCTION ABNORMALITIES AND ASSOCIATED FAC-
TORS IN KOREAN PATIENTS WITH EATING DISORDERS
Youl-Ri Kim
1
, Joon Hyung Doh
2
, Sang-Bin Bae
1
1
Department of Neuropsychiatry, Inje University Seoul Paik
Hospital, Seoul, South Korea,
2
Internal Medicine & Vision
21 Cardiac and Vascular Center, Inje University Ilsan-Paik
Hospital, Ilsan, South Korea
1. Objectives
: The aims of this study were to compare
conduction abnormalities in Korean patients with anorexia
nervosa and bulimia nervosa, and to examine its relation with
clinical and laboratory factors.
2. Methods
: We retrospectively
examined 45 women with anorexia nervosa and 75 women
with bulimia nervosa who were assessed 12-lead electrocar-
diogram as a baseline assessment. Conduction abnormalities
were measured as QT interval and corrected QT interval, QT
dispersion of the difference between the longest and shortest
QT intervals, and abnormal U wave.
3. Results
: QT interval
was significantly longer in patients with anorexia nervosa
compared with patients with bulimia nervosa. There were no
differences in QTc, QTd and abnormal U wave between pa-
tients with anorexia nervosa and patients with bulimia nervo-
sa. QTd was significantly correlated with the lowest ever life-
time body mass index (kg/m
2
) as well as the serum amylase
level in patients with anorexia nervosa.
4. Conclusions
: These
results suggest some conduction abnormalities reported in
patients with anorexia nervosa are also found in patients with
bulimia nervosa. It appears severity of weight loss and purg-
ing behavior could affect on the cardiac arrhythmia in patients
with eating disorders. Appropriate attention should be paid to
cardiac involvement in patients with eating disorders.
T36
Implicit learning in adolescent anorexia nervosa
Kerstin Konrad
1,2,3
, Verena Mainz
1,3
, Christine Firk
1,2
, Martin
Schulte-Rüther
1,3
, Beate Herpertz-Dahlmann
2
1
CHILD NEUROPSYCHOLOGY SECTION, Aachen, Germa-
ny,
2
Department of Child Psychiatry, Aachen, Germany,
3
Insti-
tute of Neuroscience and Medicine (INM-III), Jülich, Germany
Introduction: It has been suggested that Anorexia nervosa
(AN) and obsessive-compulsive disorders (OCD) share cer-
tain behavioral, neurocognitive as well as neural dysfunction.
Thus, the aim of the current study was to investigate implicit
learning mechanism in juvenile patients with AN before
and after weight rehabilitation using a serial reaction time
task (SRT) that has been shown previously to be sensitive
to assess cortico-striato-thalamic dysfunction in subjects
with OCD. Methods: We investigated 30 adolescent female
patients with AN (aged 12 to 17 years) at time of admission
to hospital (T1) and after weight rehabilitation (T2) with the
SRT paradigm. In addition, a subsample (n =16) of patients
participated in an fMRI study using the identical task. Twen-
ty-one age- and IQ-matched female controls were also tested
twice in the behavioral and fmri study. Results: Subjects with
AN showed impaired sequence learning compared to controls
at T1, but not at T2. On the neural level, we found reduced
brain activation in thalamic brain regions in AN, which was not
evident anymore at T2. Conclusions: Our data suggest that
implicit learning deficits in juvenile AN are present only during
the acute state of illness, but recover after weight-rehabili-
tation suggesting that cortico-striato-thalamic dysfunction in
juvenile AN is rather state-dependent.
T37
Night Eating Syndrom Among Women: Clinical
Characteristics, Eating Patterns and Psychopathology
Einat Lev-Ari
1
, Yael Latzer
1,2
, Miri Givon
2
, Michal Ha-
son-Rozenstein
2
1
University of Haifa, Haifa, Israel,
2
Rmbam medical center,
Haifa, Israel
Aims:
Examining the relationship between anxiety and
depression level and eating profile, among women with Night
Eating Syndrome (NES).
Methods:
52 women who request-
ed dietetic counseling, and fit the new proposed diagnostic
criteria for NES (study group), and 34 women of correspond-
POSTER SESSION 1 ABSTRACTS