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42
outcome and mental health care use. Methods: The psychiat-
ric case register of The Hague was searched for patients with
a first ED diagnosis (DSM-IV code 307.1, 307.50, 307.51)
in the period 2001-2005. For these patients the following
information will be extracted: demographic information (sex,
age at registered incidence, ethnicity) and 5-year follow-up
data consecutive on first ED diagnosis (moving window up to
2011) on ED and co-morbid diagnoses and health care con-
sumption. Preliminary results: In total, 667 patients with a first
ED diagnosis in 2001-2005 were identified, for 430 of whom
this was the main diagnosis (41 AN, 100 BN, 289 ED-NOS).
We will present treated incidence rates of ED for this period
and information on subsequent diagnostic pathways, mental
health care consumption and outcome after 5 years.
T70
IMAGING MENTAL IMAGERY IN ANOREXIA NERVOSA
Floor van Meer
1,2,3
, Paul, A.M. Smeets
1,3,4
, Unna, N. Danner
2,3
,
Roger A.H. Adan
2,3,5
, Marcel, A. van den Hout
6
1
Image Sciences Institute, University Medical Center Utrecht,
Utrecht, Netherlands,
2
Altrecht Eating Disorders Rintveld,
Zeist, Netherlands,
3
Utrecht Research Group Eating disor-
ders, Utrecht, Netherlands,
4
Division of Human Nutrition,
Wageningen University, Wageningen, Netherlands,
5
Rudolph
Magnus Institute, University Medical Center Utrecht, Utrecht,
Netherlands,
6
Department of Clinical and Health Psychology,
Utrecht University, Utrecht, Netherlands
In Anorexia Nervosa (AN), aversive images about past or an-
ticipated future pathology-related events are essential to the
maintenance of the disorder and relapse after treatment. An
effective intervention to reduce the vividness and emotionality
of these aversive memories is to tax working memory during
negative image recall, previously shown in anxiety disorders.
Taxing working memory may also be an effective intervention
for intrusive AN-related memories, considering the crucial role
of mental imagery in AN. The aim of this study is to therapeu-
tically target upsetting intrusions experienced by AN patients.
We hypothesize that taxing working memory reduces emo-
tionality of upsetting imagery and that brain responses during
retrieval of these images are diminished. In this experimental
study interventions were derived from the Eye Movement and
Desensitisation Reprocessing (EMDR) technique, of which
taxing working memory during recall has been identified as
the critical factor. 20 AN patients will participate in a functional
MRI scan session with four runs, during which negative mem-
ories will be retrieved before and after recall sessions, with or
without simultaneous eye movements. Reduction in emotion-
ality of upsetting imagery (after taxing working memory and
recall only) will be measured by subjective responses and
heart rate, reduction in brain responses will be measured with
functional MRI. Data collection is on-going and first results
will be presented at the conference.
T71
THE LINKAGE BETWEEN EATING BEHAVIOUR AND
EMOTION REGULATION IN CHILDREN: RESULTS FROM
A REFERRED SAMPLE
Julie Vandewalle, Ellen Moens, Caroline Braet
Department of Developmental, Personality, and Social Psy-
chology, Ghent University, Ghent, Belgium
Introduction: When examining childhood obesity, research
shows a strong relation between the child’s eating style and
the weight status of the child. More specific, an emotional
eating style, eating when experiencing negative emotions,
has frequently been associated with childhood obesity. This
study is based on the recent focus in literature on emotion
regulation theories. We assume that emotional eating can
be viewed as a maladaptive strategy to regulate negative
emotions. Therefore the aim of this study is to test if children
with an emotional eating style also show higher use of mal-
adaptive emotion regulation strategies. Methods: We included
overweight youngsters between the age of 10 and 16 (N =
46), who were seeking treatment. During a first visit at the
treatment centre, youngsters were asked to fill in a battery
of questionnaires. Results: First analyses show as predicted
significant positive associations between emotional eating
and the use of maladaptive emotion regulation strategies in
general. Conclusions: Further results will be discussed at the
conference. Moreover, we will present a model that can ex-
plain how family interactions can have an impact on the way
children learn to regulate their emotions.
T72
Disturbed Eating Behaviours in adolescents with Diabe-
tes type 1
Line Wisting
1
, Dag Helge Frøisland
2
, Bryan Lask
1,3
, Øyvind
Rø
1
1
Oslo University Hospital, Oslo, Norway,
2
Lillehammer Univer-
sity College, Lillehammer, Norway,
3
Ellern Mede Centre for
Eating Disorders, London, United Kingdom
Introduction
Disturbed Eating Behaviours (DEB) in Diabetes
type 1 (DM1) can lead to poor metabolic control and thus
mediate physical complications. The prevalence of DEB in
DM1 internationally is double that of healthy controls. Its
prevalence in Scandinavia, where the incidence of DM1 is
increasing more rapidly than anywhere else in the world,
is unknown. This study aims to i) assess the prevalence of
DEB in adolescents with DM1 in Norway and ii) investigate
the relationship between DEB and HbA1c (a marker of poor
metabolic control).
Methods
377 males and 387 females
in the Norwegian Childhood Diabetes Registry aged 11-20
completed the Eating Attitudes Test-12 (EAT-12) – a general
screening measure, and the Diabetes Eating Problem Survey
(DEPS), designed to identify DEB specific to DM1, such as
insulin misuse to lose weight. HbA1c was assessed in all
participants.
Results
4.9% of the females and 0.5% of the
males scored above clinical cut-off on EAT-12 (p<.01) and
27.6% of the females and 8.2% of the males scored above on
DEPS (p<.01). There was no significant correlation between
EAT-12 and HbA1c, but DEPS was significantly correlated
with HbA1c (r=0.24, p<.01).
Conclusions
Nearly 1/3 of the
females with DM1 had DEB. This is in line with previous
literature internationally. Significant gender differences were
found, indicating that females are more vulnerable to develop
DEB. DEPS seems more likely to identify patients at risk of
developing physical complications.
T74
MC4R GENE, WEIGHT REGULATION, AND EATING BE-
HAVIOUR IN BINGE EATING DISORDER
Zeynep Yilmaz
1,2
, Caroline Davis
2,3
, Allan S. Kaplan
1,2
, Robert
D. Levitan
1,2
, James L. Kennedy
1,2
1
University of Toronto, Toronto, ON, Canada,
2
Centre for
Addiction and Mental Health, Toronto, ON, Canada,
3
York
University, Toronto, ON, Canada
Introduction:
Binge eating disorder (BED) is character-
ized by regular episodes of binge eating in the absence of
compensatory behaviours. Considering its role in appetite
regulation, hypothalamic melanocortin system is a prime
candidate to investigate in BED. Although extensively re-
searched in diabetes and obesity, thus far the melanocortin
4 receptor (MC4R) gene has not been studied in BED. The
goals of this study were threefold: (1) to investigate the role of
the MC4R gene in BED; (2) to explore the link between body
mass index (BMI) and MC4R risk alleles in BED patients; and
(3) to conduct an in-depth analysis of the MC4R gene and
eating behaviour.
Methods:
We genotyped 471 probands
(114 BED, 150 obese and 207 normal weight controls) for five
MC4R markers selected based on the literature on obesity
and weight gain. Current, highest and lowest lifetime weights,
height, and several eating measures were collected during
the in-person assessment.
Results:
Analyses on eating
behaviour and MC4R are underway. We observed a trend
toward overweight probands carrying the high-risk MC4R al-
leles compared to normal weight controls. Maximum BMI was
associated with the MC4R alleles previously associated with
obesity in the entire sample (p=0.009).
Conclusions:
To our
knowledge, this is the first study to look at the MC4R gene
in BED. Based on our preliminary findings, although strongly
associated with weight regulation in the general population,
MC4R may not be linked to BED diagnosis.
POSTER SESSION 1 ABSTRACTS