44
EDRS 2013
the study.
Results:
A multiple regression model on the whole sample
was found to be significant (R
2
=.28, p<.05), suggesting RCFT scores
were able to predict DKEFS Tower scores. Within the AN group, RCFT
immediate and delayed recall scores were correlated with DKEFS
Tower scores when controlling for anxiety (r=.3, p<.05 and r=.3, p<.05
respectively). This was not found in the control group. Other comorbidities
were not found to have an effect.
Conclusions:
Findings highlight overlap
in the skills used to complete both tasks, suggesting the DKEFS Tower is
not measuring planning alone but visuospatial ability too. The importance
of considering both comorbidities and neuropsychological factors that may
maintain AN is also implicated.
F29
Examining the Effects of Menu Calorie Labeling on Restrictive Eaters
Ann F. Haynos
1
,
Christina A. Roberto
2
,
Alan E. Fruzzetti
1
1
University of Nevada, Reno, Reno, NV, USA,
2
Harvard School of Public
Health, Cambridge, MA, USA
Introduction
.
There are no data on the impact of menu calorie labeling on
disordered eating samples. Methods. 142 women completed the Dietary
Restriction Measure to establish restricting and non-restricting groups,
randomly received the same menu with or without calorie labeling, and
selected items they would consume.
Results
.
There was a condition
by group interaction on calories ordered, F(1,106) =4.25, p=.04. The
restricting group ordered fewer calories in the menu label (M=892.78)
versus no label condition (M=1413.33); calories ordered did not vary by
condition for the non-restricting group. There was a trend condition by
group interaction for estimation of calories ordered, F(1,92)=3.88,p =.05.
The restricting group was more accurate in the menu label condition
(
M=9.75) and underestimated caloric content in the no label condition
(
M=-599.50); this discrepancy was less for the non-restricting group. The
restricting group made selections more by health and emotion and had
more distress about consuming selected items in both conditions. The
restricting group reported looking at nutrition labels more frequently and
being more influenced by such information.
Conclusions
.
Menu labels
differentially affect those with and without restrictive eating tendencies.
Restricting individuals ordered less and had more accurate perception
of content when presented menu labels. Menu labels did not promote
extreme restriction or alter emotional reaction to eating for restrictive
eaters.
F30
Impulsivity Versus Self-Objectification in the Link Between Body
Shame and Disordered Eating Behaviors and Attitudes
M. K. Higgins, Anna M. Bardone-Cone, Lisa M. Brownstone
University of North Carolina-Chapel Hill, Chapel Hill, NC, USA
Body shame is a well-documented mediator of the concurrent link between
self-objectification and disordered eating, but there is reason to consider
it as a moderator, helping increase risk for disordered eating. Our aim is
to 1) test body shame as a moderator of the relationship between self-
objectification and disordered eating, 2) test body shame as a moderator
of the relationship between impulsivity and disordered eating, and 3) pit
these models against each other to investigate which interaction accounts
for the most variance in disordered eating. Female undergraduates
(
N
=244) completed a survey with questions about body surveillance
(
the manifestation of self-objectification), body shame, impulsivity, and
disordered eating (EDE-Q). Results indicated that the combination of
high body surveillance and high body shame was associated with the
highest levels of restraint, eating concern, weight and shape concern, and
driven exercise; the combination of low impulsivity and high body shame
was associated with the highest levels of restraint, eating concern, loss
of control eating, and driven exercise. Body surveillance x body shame
accounted for more variance in restraint and eating concern, whereas
body shame x impulsivity accounted for more variance in driven exercise.
Interventions should be tailored to the specific types of disordered eating
exhibited: body surveillance or body shame with elevated restraint and
eating concern; impulsivity or body shame with driven exercise.
F31
The Role of ECB1 Receptor in the Dimensional Experession of
Anorexia Psychopathology: A Pilot Pet Study Usine 11[c]Omar
Tom B Hildebrandt
1
,
Beata Planeta-Wilson
2
,
Richard E. Carson
2
,
Yiyun
Huang
2
,
Stefani Corsi-Travali
3
,
Robb Pietzark
4
,
Danielle Piompelli
5
,
Alexander Neumeister
3
1
Ichan School of Medicine at Mount Sinai, New York, NY, USA,
2
Yale
University, New Haven, CT, USA,
3
New York University, New York,
NY, USA,
4
James J, Veterans Affairs, Bronx, NY, USA,
5
University of
California, Irvine, CA, USA
Introduction:
The eCB1 system plays a primary role in extinction of
aversive conditioning and increasing the incentive motiavational properties
of food and food-mediated reward and may be dysregulated in AN.
Methods:
We investigated eCB function in 8 females (age = 25.53, SD
= 7.03) and 8 age-matched healthy controls using selective eCB1 ligand
11[
c] OMAR. Weight restored females (> 18.5 BMI) with recent AN,
having achieved stable weight for > 3 months (no change >5% weight).
Participants completed behavioral measures of food-reward based
reversal learning, disgust sensitivity, and clinical measures of eating
disorder symptomology (EDE, SCID, BDI). Statistical parametric mapping
and volume of interest anslyes of eCB1 were performed. Stepwise
regression was used to model b region specific contributions to extinction
of food-reward expectancy and disgust sensitivity in AN participants.
Results:
eCB1 availability was significantly elevated among AN patients in
the amygdala (
p
=.06,
d
=.99), insula (
p =.02, d=1.27
),
and ventral striatum
(
p
=.01, d=1.34). Regression models indicated that eCB1 availability
in the insula and amygdala explained a significant amount of variance
in extinction (
R
2
=.34,
p<.01) and disgust sensitivity (
R
2
=.31,
p=.01).
Conclusions:
Up-regulation in eCB1 receptor in AN patients may impair
extinction by increasing interoceptive sensitivity to food/disgust cues.
Improving eCB tone may be a therapeutic target for preventing relapse in
patients with AN.
F32
Demographic, Psychiatric, and Medical Profile of a Study Population
of Adults with Moderate to Severe Binge Eating Disorder: Data From
a Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial
James I Hudson
1
,
James Mitchell
2
,
Denise Wilfley
3
,
Maria Gasior
4
,
M.
Celeste Ferreira-Cornwell
4
,
Jiannong Wang
4
,
Scott Crow
5
,
Susan L
McElroy
6
1
McLean Hospital/Harvard Medical School, Belmont, MA, USA,
2
Neuropsychiatric Research Institute, Fargo, ND, USA,
3
Washington
University School of Medicine, St. Louis, MO, USA,
4
Shire Development
LLC, Wayne, PA, USA,
5
University of Minnesota Medical Center,
Minneapolis, MN, USA,
6
Lindner Center of HOPE, Mason, OH, USA
Introduction:
Baseline demographic and psychiatric characteristics of
an adult clinical trial population with binge eating disorder (BED) are
described.
Methods:
A double-blind trial of lisdexamfetamine dimesylate
vs placebo included 271 adults with BED. Entry criteria included
moderate/severe binge eating, BMI ≥25 and ≤45, Montgomery-Åsberg
Depression Rating Scale (MADRS) scores <18 and no greater than mild,
well-controlled hypertension. BED severity was assessed by binge days/
wk, Binge Eating Scale (BES), Yale-Brown Obsessive Compulsive Scale
for Binge Eating (YBOCS-BE) and Clinical Global Impressions-Severity
(
CGI-S). Anxiety symptoms were assessed by Hamilton Anxiety Rating
Scale (HAM-A) scores. BMI, vital signs and lab tests assessed medical
status.
Results:
Of 270 participants in the safety analysis set, most
were white (78.1%), female (81.5%) and ≥40 years old (49.3%). All were
overweight; 77.8% had BMI ≥30 and 18.9% had BMI ≥40. Mean (SD)
binge days/wk were 4.5 (1.33). In the full analysis set across dose groups,
most were moderately or markedly ill by CGI-S; mean BES scores ranged
from 43.9-46.9 and YBOCS-BE total scores from 19.5-20.9. Mean MADRS
and HAM-A scores ranged from 3.0-3.7 and 2.4-2.6; mean systolic and
diastolic blood pressure ranged from 117.5-121.3 and 77.0-79.0 mmHg
respectively.
Conclusions:
The study population had moderate/severe
BED, was generally obese, and lacked comorbid depression or anxiety.
Clinical research was funded by Shire Development LLC.
F33
Eating Pathology and Its Relationship to Weight Loss After Bariatric
Surgery in Labs-3
Melissa A Kalarchian
1
,
Michael J Devlin
2
,
James E Mitchell
3
1
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA,
2
Columbia University College of Physicians & Surgeons, Dept. of
Psychiatry, New York, NY, USA,
3
Neuropsychiatric Research Institute,
Fargo, ND, USA
Introduction
.
Bariatric surgery patients may evidence eating pathology
including full syndrome binge eating disorder (BED), loss of control
eating (LOC), and other subsyndromal problems. Data suggest that the
recurrence or onset of problems with LOC after operation is associated
with poor weight loss and/or regain.
Methods
.
The Longitudinal
Assessment of Bariatric Surgery (LABS) Consortium is an NIH-funded,
multi-center, observational, longitudinal study. The LABS-3 psychosocial
substudy includes a sample of patients from the parent study participating
at 3 sites. Patients were interviewed independently of the usual
preoperative psychosocial evaluation process, including administration
of the Eating Disorder Examination (EDE) adapted for bariatric surgery,
SCID-I and dietary recall.
Results
.
Among 199 patients who underwent
gastric bypass or adjustable gastric banding, most were women (82.9%)
and white (nonwhite 7.6%, Hispanic 5.0%). The median age was 46.0
years, and the median body mass index was 44.9 kg/m2. On the SCID,
13.1%
had a lifetime history of BED, and 10.1% had a current diagnosis
prior to operation. Analysis of EDE data is underway, and 3 year weight
outcomes are pending publication.
Conclusions
.
The availability of data
on LOC and a full range of eating problems in the LABS-3 sample with
routine follow-up for 3-years after bariatric surgery will allow us to examine
the temporal relationships between eating pathology and postoperative
weight loss.
POSTER SESSION 2 ABSTRACTS
