ASOPRSFall Scientific SymposiumSyllabus
192
T37
SuggestionofOptimal ResponseCriteria inPatientswithOcular Adnexal
MucosaAssociated LymphoidTissue Lymphoma
SukWooYang
1
,WonMoLee
2
, Su kyung Jung
1
.
1
Ophthalmology, St.Mary’s hospital, Seoul, SouthKorea,
2
Ophthalmology,
St.Mary’s eye clinic, Daejon, SouthKorea
Introduction:
Ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma (OAML) has been recognized asmost common
primary orbital malignancy. However, littlewas known about the response criteria for OAML.
Methods:
A retrospective chart review of 34 eyes from30 patients diagnosedwith nonconjunctival OAMLwas conducted, focusing
on the change in tumor size based on linear bi-dimensional, and three-dimensional methods inmagnetic resonance imaging (MRI)
of the orbit.Themaximum tumor response period of each casewas investigated, and the expected optimal response periodwas
calculated using regression analysis.
Results:
In 30 evaluable patients, themedian time taken for themaximum tumor responsewas 6months (range, 3-18).More than
75% of patients attainedmaximal tumor response in 6months after initial therapy for follow up period, themedian value of which
was 30months (range, 15-77). Based on the regression analysis, it took 4.7months for themaximum diameter (2r) of tumor to
decrease by fifty percent of initial lesion size.
Conclusions:
We cautiously suggest that optimal response could be defined as fifty percent reduction of themaximum diameter in
6months since the treatment was initiated, and that only observationwithout additional therapy is enough for nonconjunctival OAML,
if optimal response is achieved.
References:
Cheson BD, Pfistner B, JuweidME, et al. Revised response criteria formalignant lymphoma. J ClinOncol 2007;
25:579-586.
James K, Eisenhauer E, ChristianM, et al.Measuring response in solid tumors: unidimensional versus bidimensional measurement.
J Natl Cancer Inst 1999;91:523-528.
DetailedProgram
—Thursday,October 16, 2014
POSTERS
