ASOPRSFall Scientific SymposiumSyllabus
195
F2
Reviewof AcellularHumanDermis (AlloDerm) RegenerativeTissueMatrix in
MultipleTypes ofOculofacial Plastic&ReconstructiveSurgery
BrockAlonzo
2
, Youn-ShenBee
1
, JohnNg
2
.
1
KaohsiungVeteransGeneral Hospital, Kaohsiung, Taiwan,
2
Casey Eye Institute,
OregonHealth andScienceUniversity, Portland, OR, UnitedStates
Introduction:
This study seeks to evaluate the efficacy and factors influencing surgical outcomes using acellular human dermis
(Alloderm) inmultiple types of oculofacial plastic and reconstructive surgery.
Methods:
Retrospective review of 84 patientswho underwent surgical procedures using acellular human dermis. Preoperative
demographic data, comorbidities, tobacco use, clinical etiology, surgical methods,Alloderm thickness, and outcome (cosmetic and
functional) were evaluated.
Results:
84 patientswere included in this study, accounting for a total of 98 procedures.Mean agewas 52.5 years (3-93 years).
Etiology indications for surgery includedmalignancy (26), trauma (19), congenital lesions (15), and senile change (11). Surgical
procedures included lower lid posterior lamella elongation, socket and fornix reconstruction, scar repair, patch grafts, and filler.
Mean duration of follow upwas 530 days. Overall, 92.8% of patients had successful outcomes. Factors associatedwith significantly
worse outcomes included smoking, congenital anomaly etiologies, and previous graft/flaps in the same area (p= 0.03, p= 0.029,
p=0.007, respectively).
Conclusions:
This study suggests that Alloderm acellular human dermis can be used safely and effectively inmultiple types of
oculofacial procedures. Smoking, congenital anomaly etiologies, and previous graft/flapwere associatedwith poor cosmetic and
functional outcomes.
References:
1. ChangHS, LeeD,TabanM, Douglas RS, Goldberg RA. “En-glove” lysis of lower eyelid retractorswithAlloDerm and
dermis-fat grafts in lower eyelid retraction surgery. Ophthalmic plastic and reconstructive surgery 2011;27:137-41.
2. Dailey RA, ChavezMR. Lateral canthoplastywith acellular cadaveric dermal matrix graft (AlloDerm) reinforcement. Ophthalmic
plastic and reconstructive surgery 2012;28:e29-31.
3. Hayek B, Hatef E, NguyenM, HoV, HsuA, Esmaeli B.Acellular dermal graft (AlloDerm) for upper eyelid reconstruction after cancer
removal. Ophthalmic plastic and reconstructive surgery 2009;25:426-9.
4. Lee EW, Berbos Z, Zaldivar RA, LeeMS, HarrisonAR. Use of DermaMatrix graft in oculoplastic surgery. Ophthalmic plastic and
reconstructive surgery 2010;26:153-4.
5. Levin F,Turbin RE, Langer PD.Acellular human dermal matrix as a skin substitute for reconstruction of large periocular cutaneous
defects. Ophthalmic plastic and reconstructive surgery 2011;27:44-7.
6. Rinker B.The evils of nicotine: an evidence-based guide to smoking and plastic surgery.Annals of plastic surgery 2013;
70:599-605.
7. Rubin PA, FayAM, Remulla HD,MausM. Ophthalmic plastic applications of acellular dermal allografts. Ophthalmology
1999;106:2091-7.
8. Shorr N, Perry JD, Goldberg RA, Hoenig J, Shorr J.The safety and applications of acellular human dermal allograft in ophthalmic
plastic and reconstructive surgery: a preliminary report. Ophthalmic plastic and reconstructive surgery 2000;16:223-30.
9. Sullivan SA, Dailey RA. Graft contraction: a comparison of acellular dermis versus hard palatemucosa in lower eyelid surgery.
Ophthalmic plastic and reconstructive surgery 2003;19:14-24.
10.TabanM, Douglas R, Li T, Goldberg RA, Shorr N. Efficacy of “thick” acellular human dermis (AlloDerm) for lower eyelid
reconstruction: comparisonwith hard palate and thinAlloDerm grafts.Archives of facial plastic surgery 2005;7:38-44.
DetailedProgram
—Friday,October 17, 2014
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