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37
late postmenopausal women (aged 70 – 81).
Findings
The
absolute number of trabecules (TbN) per mm area at the
ultra distal radius of female patients with AN and healthy
postmenopausal women was significantly lower than in young
healthy participants. Mean thickness of trabecules (TbTh) and
the overall density of bone (cortical and trabecular, D100) was
significantly lower only in healthy postmenopausal women
compared to young AN patients and young healthy women.
The same pattern was found for the cortical bone (Dcomp)
and the absolute thickness of the cortex, which was signifi-
cantly lower only in healthy late postmenopausal women
compared to patients with AN and healthy young women.
Conclusions
Deterioration patterns of bone microarchitecture
over female life span and in AN are different. Troubling is the
reduced number of trabecules in both young AN patients and
healthy late postmenopausal women, compared to young
healthy controls.
T48
Prevalence of eating disorders in Switzerland
gabriella milos
1
, ulrich schnyder
1
, petra dermota
2
, meichun
mohler-kuo
2
1
university hospital , zurich, Switzerland,
2
university Division of
Epidemiology, zurich, Switzerland
Introduction
Until now, the prevalence of eating disorders in
Switzerland is still unknown. The main purpose of the study is
to assess the prevalence of the three main eating disorder di-
agnoses using DSM-IV-TR criteria with a national representa-
tive sample. In addition, we also assess the prevalence of ort-
horexie.
Methods
A national representative sample of 10’038
persons (men and women) aged 15 until 60 years were
recruited in the three principal language areas of Switzerland
(German,French, Italian). Using computer assisted telephone
interview (CATI), the lifetime prevalence of eating disorders
diagnoses based on DSM-IV-TR were assessed using WHO
Composite International Diagnostic Interview (CIDI). Orthorex-
ie was assessed with the Bratman-test.
Results
The lifetime
prevalence of anorexia nervosa, bulimia nervosa, binge eating
disorder and any binge eating disorder was 1.2%, 2.4%, 2.4
and 5.3% respectively among women, and 0.2%, 0.9%, 0.7,
and 2.9% respectively among men. One third of the surveyed
population met the criteria for orthorexia, and additionally
41% of the interviewed persons have some orthorexic habits.
Conclusions
The lifetime prevalence of eating disorder in
Switzerland is comparable with other industrialised coun-
tries, but in particular, our results showed high prevalence of
bulimia nervosa. A large proportion of the Swiss population
showed their concern about healthy diet. The implications of
the results will be discussed.
T49
INVESTIGATION OF ENDOCANNABINOID AND GASTRO-
ENTERIC HORMONE PRODUCTION IN HUMAN HEDONIC
EATING: IMPLICATIONS FOR EATING DISORDERS
Palmiero Monteleone
1,2
, Pasquale Scognamiglio
1
, Alessio
Maria Monteleone
1
, Vincenzo Di Marzo
3
, Mario Maj
1
1
Department of Psychiatry, University of Naples SUN, Naples,
Italy,
2
Chair of Psychiatry, Department of Medicine and Sur-
gery, University of Salerno, Salerno, Italy,
3
Endocannabinoid
Research Group, Institute of Biomolecular Chemistry, Consi-
glio Nazionale delle Ricerche, Pozzuoli, Naples, Italy
In hedonic eating food is consumed uniquely because of its
gustatory rewarding properties, so the subject eats also when
not in a state of short-term energy depletion. It is intuitive that
hedonic eating may stimulate powerfully food intake; hence,
understanding its physiological modulation could help to con-
trast eating disorders. In order to explore the role of endog-
enous appetite and/or reward modulators in hedonic eating,
we measured plasma levels of ghrelin, endocannabinoids,
colecystokinin-33 (CCK) and peptide YY3-36 (PYY3-36), in 8
satiated healthy subjects after ad libitum consumption of high
palatable food as compared to the consumption of isoener-
getic non-palatable food. Hedonic eating was characterized
by increased levels of ghrelin and the endocannabinoid
2-arachidonoyl glycerol (2-AG) but a decreased secretion of
the satiety hormone CCK. In both eating conditions, levels of
the other endocannabinoids anandamide, oleoylethanolamide
and palmitoylethanolamide progressively decreased while
no significant changes in plasma PYY3-36 occurred. Present
findings suggest that when motivation to eat is generated by
the availability of high palatable food and not by food depriva-
tion, a peripheral activation of the rewarding and hunger-pro-
moting signals of 2-AG and ghrelin, but a decrease of the
satiety signal of CCK occur. This could be responsible for the
persistence of peripheral cues allowing a continued eating in
spite of no energy need.
T50
Utility of the Mood Disorder Questionnaire and Bipolar
Spectrum Diagnostic Scale in the Evaluation of Eating
Disorder Patients
Toshihiko Nagata
1
, Hisashi Yamada
1
, Alan R. Teo
2
, Chiho
Yoshimura
1
1
Osaka City University Graduate School of Medicine, Osaka,
Japan,
2
University of Michigan, Ann Arbor, MI, USA
Introduction: The boundary between bipolar disorder and
borderline personality disorder has been debated. This study
investigated the utility of two bipolar disorder screening instru-
ments, the Mood Disorder Questionnaire (MDQ) and Bipolar
Spectrum Diagnostic Scale (BSDS) to assess for co-morbid
borderline personality disorder and bipolar disorder among
patients referred for eating disorders. Methods: Subjects con-
sisted of 78 consecutive female patients who were referred
or self-referred for evaluation of an eating disorder. Exclusion
criteria were limited so that subjects were most representative
of the normal clinical population. All participants completed
the mood and eating disorder sections of SCID-I/P and the
borderline personality disorder section of SCID-II, in addition
to the MDQ and BSDS. Predictive validity of the MDQ and
BSDS was evaluated by Receiver Operating Characteristic
(ROC) analysis. Results: Fifteen (19%) and twelve (15%)
subjects fulfilled criteria for bipolar II disorder and borderline
personality disorder, respectively. The Area Under the Curve
(AUC) of the MDQ was 0.78 for bipolar II disorder and 0.75
for borderline personality disorder. The AUC of the BSDS was
0.78 for bipolar II disorder and 0.79 for borderline personality
disorder. Conclusions: In a subspecialty clinical setting, the
MDQ and BSDS show promise as screening questionnaires
for both borderline personality disorder and bipolar disorder.
T51
MEDICAL FACILITIES INVOVLED IN THE TREATMNT OF
EATING DISORDERS IN JAPAN
Yoshikatsu Nakai
1
, Shun’ichi Noma
2
1
Kyoto Institute of Health Sciences, Kyoto, Japan,
2
Depart-
ment of Psychiatry, Graduate School of Medicine, Kyoto
University, Kyoto, Japan
Purpose: The aim of this study was to determine which med-
ical facilities are involved in the treatment of eating disorders
in Japan. Method: In the first stage, a letter was sent to all the
psychiatric clinics and psychiatric hospitals in Kyoto city. In
the second stage, information was obtained from chief doctors
in charge of the treatment of eating disorders by telephone
or direct interviews. Results: Kyoto city has a population of
1,400,000. The number of patients with eating disorders was
532 in 2007. Out of 532 patients, 97 (19 %) visited university
hospitals, 77 (14 %) visited general hospitals and 358 (67
%) visited clinics. Surprisingly, 325 patients visited 3 private
clinics. Of 325 patients in 3 private clinics, 91 (28 %) were
categorized as having anorexia nervosa (AN), 159 (49 %) as
bulimia nervosa (BN) and 75 (23%) as eating disorder not
otherwise specified (EDNOS). On the other hand, out of 87
patients in 3 outpatients units of university hospitals, 49 (56
%) were categorized as having AN, 33 (38 %) as BN and 5 (6
%) as EDNOS. Conclusion: These results suggest that more
than half of the patients, especially BN patients, were not
included in epidemiological studies from Japan, because the
studies were conducted in main hospitals with more than 500
beds in Japan.
POSTER SESSION 1 ABSTRACTS